What Is Eliquis (Apixaban)?
Eliquis is a direct factor Xa inhibitor, part of the class of medications called direct oral anticoagulants (DOACs). It works by blocking factor Xa, a key protein in the blood clotting cascade, which helps prevent dangerous clots from forming. It is used to reduce stroke risk in patients with nonvalvular atrial fibrillation, to treat blood clots in the legs (DVT) and lungs (PE), and to prevent clots after hip or knee replacement surgery.
ARISTOTLE Trial: Eliquis vs Warfarin
The ARISTOTLE trial (18,201 patients with nonvalvular AFib) compared apixaban 5mg twice daily against warfarin. Apixaban reduced the risk of stroke or systemic embolism by 21%, reduced major bleeding by 31%, and reduced all-cause mortality by 11% compared to warfarin. These results established Eliquis as a preferred alternative to warfarin for many AFib patients.
Eliquis Drug Facts
| Generic name | Apixaban |
| Class | Direct factor Xa inhibitor (DOAC) |
| Strengths | 2.5mg and 5mg oral tablets |
| Uses | Stroke prevention in nonvalvular AFib; DVT/PE treatment and prevention; prophylaxis after hip or knee replacement |
| Monitoring | Kidney function, liver function, and bleeding risk reviewed periodically by your clinician |
How to Use Eliquis
- Form: Oral tablet (2.5mg or 5mg).
- Frequency: Usually twice daily, as prescribed.
- With food: May be taken with or without food.
- Missed dose: Take as soon as you remember on the same day, then resume your regular schedule the next day. Do not double the dose.
- Important: Never stop Eliquis on your own without medical advice. Your risk of stroke or blood clots may increase. Discuss any upcoming surgeries, dental work, or procedures with your clinician.
Dose selection: The dose (2.5mg or 5mg twice daily) depends on your specific condition, age, weight, kidney function, and other medications. Your Vitercure clinician will determine the correct dose after reviewing your full profile. Do not adjust your dose without their guidance.
Important Safety Information for Eliquis
This is not a complete list. Always review the full Prescribing Information and speak with a licensed clinician.
Do Not Use If:
- You have active pathological bleeding.
- You have known hypersensitivity to apixaban or any component.
- Your clinician has determined anticoagulants are not appropriate for your condition.
Bleeding Risk
Eliquis increases the risk of bleeding, which can sometimes be serious or life-threatening. Seek urgent care for prolonged nosebleeds, unusual bruising, black or bloody stools, pink or brown urine, coughing or vomiting blood, or sudden severe headaches.
Common Side Effects
Easy bruising, minor nosebleeds, or mild gum bleeding can occur. Let your clinician know if these become frequent or bothersome. Serious bleeding requires emergency medical attention.
Frequently Asked Questions About Eliquis
Eliquis (apixaban) is a direct oral anticoagulant used to reduce the risk of stroke and systemic embolism in certain patients with nonvalvular atrial fibrillation. It is also used to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE), and for prevention after hip or knee replacement surgery.
Eliquis does not require routine INR blood monitoring or frequent dose adjustments like warfarin does. In the ARISTOTLE trial, apixaban reduced stroke risk by 21% and major bleeding by 31% compared to warfarin in patients with atrial fibrillation. It also has fewer dietary restrictions.
Eliquis is typically taken twice daily, with or without food. The dose (2.5mg or 5mg) depends on your specific condition, age, weight, and kidney function. Your clinician will determine the correct dose for you.
Take the missed dose as soon as you remember on the same day, then resume your regular schedule the next day. Do not double the dose. If you are unsure, contact your clinician. Never stop Eliquis without medical advice, as your clot or stroke risk may increase.
Yes. Through Vitercure, a licensed clinician reviews your medical history, bleeding risk, kidney function, and current medications through our HIPAA-compliant telehealth platform. If appropriate, they can prescribe Eliquis from licensed US, Canadian, or UK pharmacy partners.
The most important risk is bleeding, which can sometimes be serious. Common signs include easy bruising, minor nosebleeds, or gum bleeding. Seek emergency care for severe or uncontrollable bleeding, black or bloody stools, pink or brown urine, coughing blood, or sudden severe headaches.
